New disinfectants for inactivation and disinfection of Pseudomonas aeruginosa: comparison with market leaders
ABSTRACT
Background: Hospital-acquired infections are a major global burden that is largely preventable. Strict cleaning protocols and effective disinfectants are essential standard practice in healthcare settings to prevent the spread of pathogens. Nevertheless, one in twenty-five hospital patients experience at least one healthcare-associated infection.
Methods: The bactericidal efficacy of four disinfectants was tested against Pseudomonas aeruginosa using the AOAC use-dilution test. Two glutaraldehyde-based products, Microbide-G and Cidex PlusTM 28, were directly compared, and two ortho-phthalaldehyde-based products, Microbide-O and Cidex®OPA, were similarly tested. The difference between the tested agents is the micellar nature of the disinfectant in the Microbide products. All disinfectants were tested with various contact times and at two temperatures.
Results: At 20°C, Microbide-G was the only product to achieve full disinfection after three minutes of contact time, while Cidex PlusTM 28 failed up to eight minutes of contact time. Microbide-O passed after five minutes of contact time, whereas Cidex®OPA did not. At 45°C, all products performed better, but the Microbide products required less time of exposure compared to those of Cidex.
Conclusion: The results indicate that Microbide-G and Microbide-O display greater efficacies than the current commercial products for successful elimination of aeruginosa. Furthermore, the micellar nature of the Microbide products reduces volatility of the active components, decreasing respiratory exposure.
Keywords: hospital-acquired infection, Pseudomonas aeruginosa, disinfectant, AOAC use-dilution test, Microbide, Cidex
